GUTRIGHTTM IS HERE BECAUSE OUR HEALTH HAS DECLINED;
Globally our health has declined significantly in the last 50 years with the following epidemics;
- Diabetes type 2, Metabolic syndrome/Insulin resistant syndrome and Poly Cystic Ovarian Syndrome (PCOS)
- Autism and Attention Deficit Hyperactivity Disorder (ADHD)
- Anxiety and depression
- Gut problems – Inflammatory Bowel Disease (IBD) / Irritable Bowel Syndrome (IBS) / Small Intestine Bowel Overgrowth (SIBO) / Fermentable Oligo- Di- and Monosaccharides and Polyols (FODMAP) / indigestion / Reflux (GORD)
- Immune dysregulation – allergies, resistant infections, and autoimmunity
- Cardiovascular disease
But, we have hardly changed in that time!
That is not enough time for us to have evolved new genes and new genetic material across our species to explain our bad health. It is NOT human genetic polymorphisms and gene defects.
Our total calories in versus calories out have not changed enough to explain the above epidemics.
So, what has changed?
Our gut bugs have changed because our food and eating has changed.
We have two genomes, one inherited from our parents and the other acquired from our microbiome. Our inherited genome from our parents takes so many generations to change. Mathematical models suggest we have the ability to change 0.05% of our genetic material over 100,000 years. On average, in DNA sequence, each human is 99.5% similar to any other human. While our inherited genome hardly changes if at all during our lifetime, the microbiome genome is extremely dynamic and can be constantly changing, even from night and day. The human gut microbiome accounts for more than 5 million different genes that is 100 x the number of genes we possess. Some of the genes encoded by the human core microbiome build systems required for their human host survival, but not present in our human genome.
Our gut microbiota consists of more than 10 trillion microbial cells, which is about 10X the number of our own cells making up about 1–2 kg of our body weight. Our gut bugs play a very active role in our energy metabolism and immune and inflammatory systems.
There is a common link between the above epidemics, a particular change in our gut flora driving these diseases. There are more than 1000 microbial strains but 90% of the biomass consists of firmicutes and bacteroidetes. The ratios between the firmicutes and bacteroidetes will determine your metabolic rate and the degree of inflammation your body experiences and this can be the difference between winning and losing in life.